One of the main arguments supporting the application of the natural ventilation is the reduction inenergy consumption and capacity of the HVAC system. Here several tests of the building with different systems are carried to quantify the differences in capacities and energy consumptions of different solutions for the HVAC system. The tests were carried with the simulation program built in Simulink. To validate the model the measurements were done in Test cell at TU Delft as well as in the real office building. With the validated simulation model several options of the building set-up could be compared concerning the energy consumption and comfort level.