This study is concerned with the impact of indoor environment on the local National health in airconditioned spaces. The present study is carried out in different applications in Egypt. Two differentmethods are utilized in the present study. An experimental measurement program and comprehensive survey are carried out for some air conditioned applications. The numerical methodsare also utilized to simulate applications that represent the effect of indoor environment onoccupancy health using different indoor air quality indices. The present study is carried out in different applications of healthcare hospitals, commercial buildings and residential premises etc.