SYSTEMIC STUDIES ON MOLECULAR MECHANISMS FOR NON-ALLERGENIC AIR POLLUTANT FORMALDEHYDE-INDUCED ASTHMA

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Yang, X.; Soron, K.K.; Qiao, Y.; Molhave, L.; Zhou, E.; Yan, Y.; Peng, G.; Cao, Y.; Zhu, Y.; Ke, K.; Ding, S.; Yuan, J.
Prevalence, Acquired atopy, Molecular mechanism, asthma, formaldehyde
Year:
2007
Bibliographic info:
The 6th International Conference on Indoor Air Quality, Ventilation & Energy Conservation in Buildings IAQVEC 2007, Oct. 28 - 31 2007, Sendai, Japan

In past 20 years, the average prevalence of asthma in China has been growing up from 0.9 % to about3.0 %. We carried out these studies to find out the reasons and relative molecular mechanisms. Datamultiple-regression was used for prevalence and risk factor investigation (1990-2000) and animalexperiments were used for mechanism study. According to multiple-regression, 10 statistical items, inwhich some of the items are building related factors, were found to be the asthma risk factorssignificantly; in the animal model of formaldehyde induced asthma, vanilloid receptor, thymicstromal-lymphocytes protein and S-nitrosoglutathione reductase were found to have important roles inasthma initiation and promotion.

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