Heat stress associated with extreme temperatures and relative humidity has been shown to reduce the productivity from swine facilities, especially breeding facilities. Traditional cooling methods used in these settings include evaporative pad cooling or misting with water. These methods are unable to lower relative humidity. Direct-expansion air- conditioning (DX-AC) has been shown to be effective, but generally not economically feasible at current energy costs. This paper presents an analysis of a desiccant technology for dehumidification configured with different ventilation systems, to enhance different cooling methods including evaporative pads. Results from this study suggest that cost-effective hybrid desiccant systems may be designed to effectively eliminate stress conditions in a high-value swine breeding operations.