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A desiccant cooling unit powered by 14.8 m2 of solar liquid collectors is implemented in a training room in Chambery in Eastern France. The system uses a Lithium Chloride sorption wheel and is optimized to work without auxiliary heat regeneration source. Several parameters are studied in order to decrease primary energy consumption and increase system performance. The models are implemented in SimSPARK a simulation environment linked with energy+ and able to solve complex problems. Simulations show that humidifiers efficiencies and rotating heat exchanger efficiency have major influences on the system performance. Besides it was shown that airflow rate during inoccupation period is a key component in the operation of the system. Our results suggest that an airflow rate of 2.8 AC/H during inoccupation decreases required regeneration hours by about 40%, decreases room required cooling factor about 62% while electricity consumption increases only about 8%.