This paper provides an overview of existing guidance, regulations, and design approaches to control diesel exhaust from locomotives operating in buildings. First, design guidance and standards for exposure to major components of diesel exhaust are reviewed. Next, issues regarding engine design, fuel composition, and outdoor emissions control strategies and their potential impact on current and future indoor emissions are discussed. Ventilation approaches that have been implemented in existing facilities are also presented. The review highlights both approaches and information that will be useful to designers planning or retrofitting this type of facility.