This paper describes how the energy performance of single storey multiple-skin facades can be optimized by changing the settings of the facades and HVAC system. The energy performance is analyzed with a yearly whole building energy analysis under Belgian climatic conditions. Three multiple-skin facades are scrutinised: a mechanically ventilated airflow window, a naturally ventilated double-skin facade and a mechanically ventilated supply window. Their performance is compared against the performance of a traditional cladding with exterior and interior shading device. It is shown that both the heating and cooling demand may significantly be improved by implementing control strategies such as controlling the airflow rate and recovery of air returning from multiple-skin facades.