In predicting flow rate of a building ventilated by wind, the orifice equation is usually used. This conventional method cannot work for the building provided with large openings. Therefore, the final goal of this study is to establish a new prediction method of the cross-ventilation rate, which is based on energy balance inside the stream tubes passing through/around a building. In determining stream tubes, it is beneficial to use CFD. In this study, the accuracy of CFD analysis is studied. Three turbulence models are used in the simulation; i.e. Standard k- Model Reynolds Stress Model, and Large Eddy Simulation. As a result, we can state the accuracy of Large Eddy Simulation is better than other CFD models.