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Recent advances in mathematical models, computer processors and OOP compilers have been motivating the development of the Domus program for whole-building hygrothermal simulation. The Domus program for simulation of multi-zone buildings has been developed in c++ language under C++ Builder environment, which is a fast and precise easy-to-use compiler. The program is available on the PC platform under Windows 9x and NT operating systems. The user interface consists of a series of windows in which the user can enter the relevant input data and review the results. The user can move between other applications when the Domus simulations are running and several Domus projects can be open and running at the same time due to the independence of the graphical interface and the thermal simulation engine. Domus projects with all their input information and results may be saved and reopened. The Domus former version allows the calculation of building thermal and energy performance, neglecting moisture effects. In this Domus version, the interface has been considerably improved so that simulations can be performed in a very-easy way. Additionally, the Umidus program features have been inserted into the Domus code, allowing it to take moisture effects into account. In Conclusion, Domus interface is presented and a hygrothermal simulation of a 3-storey building in discussed.